Kobe University · University Hospital · 助教

Research keywordsdiagnostic radiology・head and neck cancer・magnetic resonance imaging・gadolinium safety・prostate diffusion imaging・lung PET MRI

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• Summary of Japanese clinical practice guidelines for head and neck cancer - 2025 update edited by the Japan Society for Head and Neck Cancer.2025 · The Japanese Clinical Practice Guidelines for Head and Neck Cancer - 2025 Edition were developed to provide clear evidence-based recommendations that reflect recent advancements and evolving clinical needs in head and neck cancer care. Advances in immunotherapy, targeted therapies, surgical techniques, and genomic medicine have expanded treatment options and added new complexities. This edition offers practical, up-to-date guidance to support consistent decision making across diverse clinical scenarios. Compared with the 2022 edition, the guidelines have been substantially expanded to 63 clinical questions (CQs) across 14 categories. A new feature is the inclusion of commentary columns that address clinically important topics not suited to the CQ format, such as special patient populations, novel therapies, and rare malignancies. To reflect the growing role of precision oncology, updated recommendations for molecular-targeted treatments have been added based on specific genomic alterations, in alignment with the current approvals in Japan. While maintaining the structure of previous editions, this edition addresses the changing clinical environment while also helping to inform future discussions and directions in head and neck cancer care.
• Clinical and Imaging Features of Syphilis from Head to Toe.2025 · Syphilis, a bacterial infection caused by Treponema pallidum, is resurging globally. It is classified as acquired or congenital syphilis. Acquired syphilis progresses through primary, secondary, and tertiary stages. Pathologically, acquired syphilis is characterized by vasculopathy, perivascular infiltrates in syphilitic lesions, and reactive lymphadenopathy. Primary and secondary syphilis frequently manifest with cutaneous and mucosal lesions accompanied by extensive lymphadenopathy at the initial sites of sexual contact, such as the genitalia, oropharynx, and anorectum. These manifestations may mimic malignancies. Tertiary syphilis encompasses cardiovascular syphilis, late neurosyphilis, and gummas, each manifesting distinct imaging characteristics. Most acquired cases are suspected on the basis of dermatologic signs and patient history and are confirmed serologically. Imaging findings alone may not be diagnostic and can overlap with those of other infectious, inflammatory, or neoplastic conditions, necessitating clinical correlation and laboratory testing. However, in patients with atypical clinical presentations, imaging has an important role in providing valuable diagnostic clues and guiding appropriate clinical treatment. The incidence of congenital syphilis is also increasing in parallel with the overall increase in syphilis infections. A comprehensive understanding of the diverse imaging manifestations in multiple organ systems is vital for radiologists to accurately diagnose and guide appropriate management in the era of resurgent syphilis. The authors provide an overview of acquired and congenital syphilis, detailing the epidemiologic and pathophysiologic characteristics, diagnostic approaches, clinical courses, and imaging features. ©RSNA, 2025 Supplemental material is available for this article.
• Author Correction: Bilateral adrenal uptake of 123I MIBG scintigraphy with mild catecholamine elevation, the diagnostic dilemma, and its characteristics.2022 · 2022年08月, Scientific reports, 12(1) (1), 13238 - 13238, 英語, 国際誌
• Adrenocortical adenoma arising from adreno-hepatic fusion: A pitfall for an overdiagnosis.2022 · 2022年12月, Pathology international, 73(1) (1), 61 - 63, 英語, 国際誌

• 新生児呼吸器疾患に対するAI（人工知能）活用：診断の標準化と予後予測のために 伊藤 直樹, 石黒 秋生, 神田 知紀, 高橋 和浩 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 帝京大学, 2024年04月01日 - 2027年03月31日2024 · KUID parsed section
• 先天性腎尿路異常の新規診断法の開発：被曝と侵襲のない検査をめざして 高橋 和浩, 神田 知紀, 山本 麻子, 西野 智彦 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 帝京大学, 2022年04月01日 - 2025年03月31日2022 · KUID parsed section
• 脳剖検組織を用いた正常腎機能におけるガドリニウム造影剤残留量の定量評価 神田 知紀 日本学術振興会, 科学研究費助成事業, 若手研究(B), 帝京大学, 2015年04月01日 - 2017年03月31日2015 · KUID parsed section
• 小児腎炎の非侵襲的組織診断方法の開発：MRI拡散テンソル画像による組織診断 高橋 和浩, 神田 知紀, 中村 明夫, 古井 滋, 関根 孝司 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 帝京大学, 2014年04月01日 - 2018年03月31日 腎生検による病理組織診断は腎炎治療に不可欠だが侵襲が大きく合併症リスクも高い。小児では生検に鎮静を要するなど負担が成人よりも大きい。MR拡散テンソル画像(DTI)は生内水分子の拡散量と方向を画像化する手法である。DTIを用いたTractography(TG)は水分子拡散の異方性を追跡する方法で、中枢神経領域では白質の神経線維走行を可視化できるため、脳外科手術のシミュレーションなどへの応用が進んでいる。本研究では小児腎炎患者でTGを描出し、描出された線維の数と長さは腎の線維化の程度と逆相関する可能性が示唆された。TGは造影剤不要で繰り返し施行可能であり、腎線維化の経時的な追跡に有用と考えられる。2014 · KUID parsed section

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