Kobe University · Graduate School of Medicine / Faculty of Medicine · 教授

Research keywords分子病理学・asthma-COPD overlap・ゲノム病理学・マルチオミックス解析・間質性膀胱炎・肺癌・空間トランスクリプトーム・神経内分泌癌

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• Clinicopathological significance of loss of Y chromosome in male meningiomas.2026 · Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high-grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in various male-predominant tumors, a limited number of studies have evaluated their role in meningiomas. To evaluate the clinicopathological significance of Y chromosome loss in male meningiomas, we assessed the frequency of loss of the Y chromosome (LOY) using droplet digital polymerase chain reaction in combination with multiplex ligation-dependent probe amplification on tumor DNA from 93 male meningioma samples. LOY, detected in nine cases (9.7%), was significantly associated with a higher World Health Organization tumor grade (grade 2: 55.6% versus 14.3%; grade 1: 44.4% versus 85.7%; p = 0.009) and loss of the NF2 gene-encoded protein, moesin-ezrin-radixin-like protein (merlin) (loss: 88.9% versus 50.0%; retained: 11.1% versus 50.0%; p = 0.035). RNA in situ hybridization targeting KDM5D on formalin-fixed paraffin-embedded tissue sections demonstrated a sensitivity of 100% (9/9) and a specificity of 76.2% (64/84) for LOY detection, supporting its utility as a screening modality. Moreover, spatial transcriptomic analysis revealed significant differences in the expression of genes associated with epithelial-mesenchymal transition and extracellular matrix organization between LOY and non-LOY meningioma tumor cells. Our findings emphasize the presence of atypical pathological features and distinct transcriptional profiles in LOY-associated meningiomas. © 2026 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
• 大腸癌の進展に伴うがん関連線維芽細胞の不均一性の解明(Challenges to cancer-associated fibroblasts' diversity in colorectal carcinoma along its progression)2025 · (一社)日本病理学会, 2025年03月, 日本病理学会会誌, 114(1) (1), 323 - 323, 英語
• 食道扁平上皮癌細胞と共培養した癌関連線維芽細胞において発現亢進するビグリカンの解析(Analysis of biglycan upregulated in cancer-associated fibroblasts co-cultured with ESCC cells)2025 · (一社)日本病理学会, 2025年03月, 日本病理学会会誌, 114(1) (1), 353 - 353, 英語
• 膵上皮内癌・微小浸潤癌の腫瘍免疫微小環境に関する免疫組織化学的検討(Tumor immune microenvironment in isolated high-grade PanIN and microinvasive PDAC: an IHC study)2025 · (一社)日本病理学会, 2025年03月, 日本病理学会会誌, 114(1) (1), 345 - 345, 英語

• 性差に着目した間質性膀胱炎の病態解明研究 前田 大地, 堀江 真史 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2026年04月 - 2029年03月2026 · KUID parsed section
• 間質性膀胱炎の患者登録と診療ガイドラインに関する研究 秋山 佳之, 堀江 真史 厚生労働科学研究費, 難治性疾患政策研究事業, 2026年04月 - 2027年03月, 研究分担者2026 · KUID parsed section
• 単一細胞マルチオミックスによるクロマチン動態と脳動静脈奇形発生機構の解明 伊藤 行信, 堀江 真史 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 金沢大学, 2026年04月 - 2029年03月2026 · KUID parsed section
• 特発性肺線維症の急性増悪に対する新規治療薬の創出を目指した研究 渡辺 知志, 堀江 真史 日本医療研究開発機構（AMED）, 橋渡し研究プログラム「橋渡し研究推進による未来医療創出」, 2026年04月 - 2027年03月, 研究分担者2026 · KUID parsed section

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