Kobe University · Research Center for Advanced Biotechnology

Research keywordsmetabolic engineering・anthraquinone biosynthesis・Escherichia coli・actinomycete metabolites・thiopeptide bioengineering・biosynthetic gene clusters・hyperspectral metabolite imaging

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• Development of a High Anthraquinone-Producing Escherichia coli Strain Using Malonyl-CoA Supply Pathway Engineering2025 · 2025年09月, ACS Synthetic Biology
• Development of a method for quantifying metabolites in Escherichia coli colonies using hyperspectral imaging2025 · 2025年10月, Journal of Bioscience and Bioengineering
• Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides.2024 · Covering: This review summarizes recent advances in the discovery, biosynthesis, and bioactivity of RiPP-derived lipopeptides, covering studies published up to 2024.Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse superfamily of natural products unified by a common biosynthetic logic: The peptide backbone is genetically encoded, and the translated precursor peptide undergoes a series of post-translational modifications catalyzed by maturase enzymes to produce the final bioactive compound. Despite their structural complexity, RiPPs are encoded by relatively small biosynthesis gene clusters. RiPP maturase enzymes are diverse and often promiscuous, offering significant biotechnological potential. However, their lack of conserved features makes genome-based discovery of novel RiPPs challenging. Recent advances in biosynthetic understanding and genome mining techniques have led to the identification of numerous uncharacterized RiPP biosynthetic gene clusters, often flanked by genes encoding non-RiPP moieties, in microbial genomes. Leveraging this information, a new class of natural products, hybrids of RiPPs and non-RiPP elements, has recently been discovered. Among them, RiPPs bearing fatty acyl groups, referred to as RiPP-derived lipopeptides, represent a newly emerging class of lipopeptide natural products with significant antimicrobial activity.
• Insights into Arsenic Secondary Metabolism in Actinomycetes from the Structure and Biosynthesis of Bisenarsan2023 · American Chemical Society (ACS), 2023年08月, Journal of the American Chemical Society, 145(32) (32), 17863 - 17871, 英語

• RiPPリポペプチドのリピデーション化学 浅水 俊平 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2026年04月01日 - 2029年03月31日2026 · KUID parsed section
• 放線菌の分枝発生メカニズムの解析と応用 公益財団法人発酵研究所（IFO）, 2024年04月 - 2026年03月2024 · KUID parsed section
• 酵素プロミスキュイティと生合成工学的手法を用いた非天然 RiPP型リポペプチドの生合成 2024年度 ノボザイムズ ジャパン研究ファンド, 2024年01月 - 2024年12月2024 · KUID parsed section
• ミコール酸含有細菌の接触刺激による放線菌二次代謝応答機構の変異ゲノム解析を用いた解明 公益財団法人発酵研究所（IFO）, 2018年04月 - 2020年03月, 研究代表者2018 · KUID parsed section

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