Kobe University · Graduate School of Medicine / Faculty of Medicine · 助教

Research keywordssuicide genetics・MIF promoter polymorphism・telomere shortening・schizophrenia genetics・chromosome Y loss

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• 日本人自殺既遂者におけるMIF遺伝子プロモーター領域機能的多型の関連解析2017 · 2017年09月, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回, 日本語
• 自殺既遂者におけるテロメア異常短縮2017 · 2017年09月, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回, 日本語
• Investigation of chromosome Y loss in men with schizophrenia.Background: Life expectancy is 10-20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. Materials and methods: The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Results: There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03-1.19]). Conclusion: According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia.

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