Kobe University · University Hospital · 助教

Research keywordsmedication-related osteonecrosis of the jaw・osteoradionecrosis・oral squamous cell carcinoma・dental oncology・gingival cancer angiogenesis・infective endocarditis oral microbiology・dental abnormalities in cancer survivors

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• 周術期のオーラルマネジメントによる外科感染症の予防 歯とHeartとの関連2024 · (一社)日本外科感染症学会, 2024年10月, 日本外科感染症学会雑誌, 21(1) (1), 198 - 198, 日本語
• Association between bacteria detected in blood and the oral environment in patients with infective endocarditis.2018 · INTRODUCTION: Infective endocarditis (IE) is a rare disease with a high mortality rate. Although IE is often associated with dental treatment, poor oral hygiene has also been reported to contribute to development, even in the absence of dental procedures. Therefore, oral surgeons may play an important role in the prevention of IE through oral hygiene management and therapeutic interventions. Few studies have examined the relationship between the causative bacteria in patients with IE and their oral environment. We therefore retrospectively investigated the bacteria detected by blood culture and the oral environment of patients treated for IE. METHODS: The study sample comprised 48 patients who underwent IE treatment from October 2018 to April 2024. We evaluated the correlation between the number of teeth indicated for extraction, as determined by panoramic radiography and intraoral examination, and the bacteria detected in blood culture tests performed during IE treatment. RESULTS: The final study cohort comprised 31 patients. Among the bacteria detected by blood culture, seven were classified as intraoral and five as extraoral. The number of teeth indicated for extraction was significantly higher in patients with IE caused by intraoral bacteria than in those with IE caused by extraoral bacteria. CONCLUSIONS: Careful dental monitoring is essential to prevent deterioration of oral hygiene. When dental treatment is deemed necessary, early intervention before caries progresses is critically important.
• Identifying the clinical indicator for surgical intervention in medication-related osteonecrosis of the jaw.2010 · INTRODUCTION: Surgery has increasingly been reported as an effective treatment for medication-related osteonecrosis of the jaw (MRONJ), but concrete intervention criteria are lacking. On computed tomography (CT) images, the boundary between the healthy site and necrotic lesion, which we defined as "MRONJ demarcation line", is sometimes visible. This study aimed to identify the factors associated with this boundary to improve surgical planning. MATERIALS AND METHODS: 95 patients with MRONJ who underwent their first CT at our institution between May 2010 and June 2022 were included. The Mann-Whitney U test, Fisher's exact test, and multivariate logistic regression analysis were performed. The cumulative incidence rates were calculated using the Kaplan-Meier method. Statistical significance was set at p
• Effect of Statins on Patients With Osteoradionecrosis of the Jaw.2008 · BACKGROUND: Osteoradionecrosis of the jaw (ORN) is a late complication of radiation therapy. Radiation-induced fibrosis is the most likely mechanism for developing ORN, and statins are effective against radiation-induced fibrosis. However, no reports have indicated the direct effectiveness of statins in treating ORN. PURPOSE: This study aimed to measure the association between statin exposure and ORN disease resolution. STUDY DESIGN, SETTING, SAMPLE: This retrospective cohort study included patients with ORN diagnosed between January 2008 and December 2020 at the Hospital's Department of Oral and Maxillofacial Surgery. Patients who were immunocompromised or followed up for

• 移植筋弁の経年萎縮を予防しうる治療法開発 村木 友美 日本学術振興会, 科学研究費助成事業, 若手研究, 神戸大学, 2025年04月01日 - 2029年03月31日2025 · KUID parsed section
• 移植筋弁の経年萎縮を予防しうる治療法開発
• 生体に害の少ない口腔癌に有効な新規抗癌剤候補分子の探索

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