Kobe University · Graduate School of Medicine / Faculty of Medicine

Research keywordsoral squamous cell carcinoma・medication-related osteonecrosis of the jaw・osteoradionecrosis・cancer-associated fibroblasts・maxillofacial surgery・transcutaneous carbon dioxide therapy

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• 自傷行為により側頭筋および咬筋に発症した外傷性化骨性筋炎の1例2024 · 2024年, 日本口腔外科学会雑誌, 70(6) (6)
• The Efficacy of Carbon Dioxide Paste in Alleviating Pain in Patients After Neck Dissection: Protocol for a Double-Blinded, Randomized Controlled Trial.2021 · BACKGROUND: Head and neck cancers that cause severe aesthetic and functional disorders normally metastasize to the cervical lymph nodes. Patients with cervical lymph node metastasis are undergoing neck dissection. Shoulder complaints are common after neck dissection, with patients reporting symptoms such as pain, weakness, shoulder droop, and disability. However, no safe and effective treatment is available for this condition at present. We will conduct a double-blinded, randomized controlled trial to evaluate the efficacy of carbon dioxide (CO2) paste in relieving pain in patients after neck dissection. OBJECTIVE: This will be the first clinical study to compare the efficacy of CO2 paste with placebo in relieving postoperative pain in patients who underwent neck dissection. METHODS: We will perform this trial at the Kobe University Hospital in Japan. Patients will be randomized 1:1 into the CO2 paste and control groups. Patients in the CO2 paste group will have the CO2 paste applied to the cervical surface skin for 10 minutes once per day for 14 consecutive days. The primary end point of the study is a change in the visual analog scale (VAS) scores of neck pain from baseline on day 1 (preapplication) to the end of drug application (day 15). Secondary end points include changes in the following parameters from baseline on day 1 to the end of drug application (day 15) or the study (day 29): neck pain VAS score (days 1-29), grip strength (days 1-15 and 1-29), VAS scores for subjective symptoms (the feeling of strangulation, numbness, swelling, and warmth in the neck and shoulder region) for days 1-15 and 1-29, whether the VAS score improved more than 30% (days 1-15), the arm abduction test (days 1-15 and 1-29), shoulder range of motion (abduction and flexion) for days 1-15 and 1-29, occurrence of skin disorders, and occurrence of serious side effects. Periodic monitoring will be conducted for participants during the trial. This study was approved by the certified review board of Kobe University. RESULTS: The intervention commenced in May 2021 and will continue until March 2024. The collected data will provide information on the efficacy of the CO2 paste treatment. The primary end point will be compared using the Wilcoxon test, with the 1-sided significance level set at 5%. Each evaluation item will be summarized. Secondary efficacy end points will be analyzed to provide additional insights into the primary analysis. Findings based on the treatment effects are expected to be submitted for publication in 2025. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of CO2 paste in relieving pain in patients after neck dissection. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) identifier: jRCTs051210028; https://jrct.niph.go.jp/en-latest-detail/jRCTs051210028. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/50500.
• Identifying the clinical indicator for surgical intervention in medication-related osteonecrosis of the jaw.2010 · INTRODUCTION: Surgery has increasingly been reported as an effective treatment for medication-related osteonecrosis of the jaw (MRONJ), but concrete intervention criteria are lacking. On computed tomography (CT) images, the boundary between the healthy site and necrotic lesion, which we defined as "MRONJ demarcation line", is sometimes visible. This study aimed to identify the factors associated with this boundary to improve surgical planning. MATERIALS AND METHODS: 95 patients with MRONJ who underwent their first CT at our institution between May 2010 and June 2022 were included. The Mann-Whitney U test, Fisher's exact test, and multivariate logistic regression analysis were performed. The cumulative incidence rates were calculated using the Kaplan-Meier method. Statistical significance was set at p
• Prognostic Value of Pretreatment Neutrophil-to-Lymphocyte Ratio in Osteoradionecrosis.2010 · BACKGROUND: Osteoradionecrosis (ORN) is a severe adverse effect of radiation therapy for head and neck cancers. Despite advances in radiation techniques and surgical management, reliable predictors of ORN prognosis remain lacking. PURPOSE: The purpose of this study was to measure the association between systemic inflammatory biomarkers and ORN prognosis. STUDY DESIGN, SETTING, SAMPLE: This retrospective cohort study included patients with ORN treated between January 2010 and March 2022 at the Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine. Patients with unavailable blood test data were excluded. PREDICTOR VARIABLE: The predictor variables were pretreatment systemic inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio (LMR). The cutoff values for NLR, platelet-to-lymphocyte ratio, and LMR were determined using receiver operating characteristic curve analysis. Each marker was calculated at the time of diagnosis of ORN. MAIN OUTCOME VARIABLE: The outcome variable was prognosis. Subjects had a good prognosis if the ORN stage improved. The prognosis was poor if the ORN stage was stable or worse over time. COVARIATES: Sex, age, stage, onset region, primary tumor site, radiation dose, smoking history, medical history, steroid therapy, clinical symptoms, treatment methods, and computed tomography image findings were covariates. ANALYSES: Statistical analysis was performed using Mann-Whitney U nonparametric test, Fisher's exact test, χ2 test, and Cox regression analysis. Statistical significance was set at P

• 病的骨破壊における破骨細胞の時空間的解析と治療への応用 田所 慶誠 日本学術振興会, 科学研究費助成事業, 若手研究, 神戸大学, 2025年04月01日 - 2027年03月31日2025 · KUID parsed section
• 生体イメージング技術を駆使した顎骨壊死の病態解明と新規治療法の探索 田所 慶誠 日本学術振興会, 科学研究費助成事業, 研究活動スタート支援, 神戸大学, 2024年07月31日 - 2026年03月31日2024 · KUID parsed section
• 生体イメージング技術を駆使した顎骨壊死の病態解明と新規治療法の探索
• 病的骨破壊における破骨細胞の時空間的解析と治療への応用

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