Kochi University · Graduate School of Integrated Human and Natural Sciences · 准教授

Research keywordsATP-sensitive potassium channels・primary afferent neurons・pain nerve injury・neuropharmacology・propofol pharmacology・potassium currents

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• The involvement of the neurosteroid allopregnanolone in the anti-hyperalgesic effect of paroxetine in a rat model of neuropathic pain
• Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons action by direct S-nitrosylation
• Suppressed Ca^<2+>/CaM/CaMKII-dependent K_ channel activity in primary afferent neurons mediates hyperalgesia after axotomy
• Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes

• 全身麻酔による脳内神経炎症機構の解明 -高齢者に最適な麻酔法の確立をめざして-
• 加齢に関連する痛みの慢性化機序の解明 -脳由来神経栄養因子の役割とその治療応用-
• In vivoイメージングを活用した全身麻酔による脳ミクログリア機能変容解析
• 冠動脈平滑筋細胞のATP感受性K^+チャネルに及ぼす麻酔薬の影響

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