Kochi University · Graduate School of Integrated Human and Natural Sciences

Research keywordsElongin A・ubiquitin ligase・DNA damage response・transcription elongation・amyloid precursor protein・insulin resistance signaling・S-nitrosylation・skeletal muscle apoptosis

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• NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation2020 · Cell Reports
• iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53.2017 · PloS one
• Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage2017
• Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses2015

• アルツハイマー病の新規治療薬の開発に向けたNRBP1-ユビキチンリガーゼ阻害剤の探索2024
• 新規アルツハイマー病治療薬創出に向けたNRBP1-ユビキチンリガーゼ阻害剤の探索2021
• 新規ユビキチンリガーゼを標的とするアルツハイマー病の治療薬開発に向けた基盤研究2018
• 神経分化における伸長因子Elongin Aの標的遺伝子の探索とその制御機構の解明2015

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