Kochi University · Graduate School of Integrated Human and Natural Sciences · 教授

Research keywords分子標的治療・p53・造血器腫瘍・FLT3・AML・Mcl-1・アポトーシス

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• Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
• Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma.
• Low-dose melphalan for treatment of high-risk myelodysplastic syndromes.
• Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100.

• 血球貧食症候群の発症に関わるリンパ球増殖のクローン解析
• p53シグナルの機能的ヒエラルキー変化による悪性リンパ腫の分子標的治療耐性の解明
• 造血器腫瘍のBCL-2特性に基づくp53依存＋非依存性ミトコンドリア死の分子誘導
• 成人T細胞白血病・リンパ腫の進展におけるエピゲノム異常の網羅的解析

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