Kyoto Prefectural University of Medicine · Faculty of Medicine · 助教

Research keywordsγ-グルタミルシクロトランスフェラーゼ・がん生物学・がん予防

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• Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase.
• Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model.
• γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
• A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer.

• 新規RB抑制因子GGCTの阻害による「RB活性化がん予防法」の開発
• 「RB再活性化スクリーニング」によるGGCTを標的とした新規がん予防法の開発
• BRAF変異悪性黒色腫に対する新規分子標的治療法の開発
• 遺伝性乳がん卵巣がん症候群に対する先制医療の開発

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