Kyoto Prefectural University of Medicine · Graduate School of Medicine · 教授

Research keywords骨代謝・インスリン・SIRT7・脱アセチル化・膵β細胞・脂質代謝・メカニカルストレス

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• Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: Studies using VDR knockout mice
• In vivo function of VDR in gene expression-VDR knock-out mice
• RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor kappa B ligand expression induced by BMP-2 in primary osteoblasts
• SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice.

• 骨芽細胞と靭帯・腱細胞の分化制御機構とメカニカルストレス応答性に関する研究
• 中鎖脂肪酸修飾タンパク質による新たな運動器恒常性維持機構の解明
• SIRT7の多面的代謝作用の解明およびその制御法の開発
• 新規アシル化翻訳後修飾による代謝制御の分子機構解明

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