Kyoto Prefectural University of Medicine · Unclassified · 特任教授

Research keywordscancer chemoprevention・molecular oncology・histone deacetylase inhibitors・cell cycle control・colon carcinogenesis・targeted cancer prevention・CDK profiling

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• [Development of novel epigenetic molecular-targeting agents].
• Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.
• Molecular mechanisms of the antitumor activity of SB225002: a novel microtubule inhibitor.
• The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line.

• ヒストン脱アセチル化酵素阻害剤によるP21/WAF1遺伝子誘導機構の解析
• 癌に対する転写調節予防及び治療法
• 食物繊維由来の酪酸による大腸癌に対する予防効果の作用機構の検討
• RBファミリー増強による新規がん予防法の開発

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