Sojo University · Faculty of Pharmaceutical Sciences · 講師

Research keywordsantibody fragment engineering・Fab stabilization・disulfide bond engineering・thermostability analysis・glycosylation-free antibody design・protein engineering・interchain disulfide bonds・Fab constant domains

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• タンパク質工学的手法による抗体フラグメントFabの高機能化に関する基盤研究2025 · YAKUGAKU ZASSHI
• Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains.2024 · Biochem. Biophys. Res. Commun.
• Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab.2023 · J. Biochem.
• Enhancing thermal stability in the CH2 domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris.2023 · Protein Sci.

• がん治療を目指した新規耐熱型Fabイムノトキシンの開発2025
• ハブ由来培養細胞と不酵素活性型ハブ毒成分が示す新奇な生命現象の解明2023
• ハブ咬傷治療薬開発を目指した筋壊死因子標的型高親和性Fabの創製2021
• FabエンジニアリングによるADAs産生抑制に関する研究基盤の確立2019

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