Sojo University · Faculty of Pharmaceutical Sciences · 准教授

Research keywordsProtein-Protein/lipid/carbohydrate interactions・Diaclyglycerol kinases・Innate immune responses・Lipid kinases・Multidomain enzymes

Research fieldsStructural biochemistry・Biophysics・薬系衛生、生物化学

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• Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock.
• Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis.
• Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants.
• Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System.

• Understanding the efficacy of therapeutic antibodies through their interaction with cellular receptors.
• ジアシルグリセロールキナーゼαが癌細胞増殖を促す一方でT細胞を不活化する分子機構
• シグナル脂質代謝酵素DGKαの触媒機構及び分子内活性化制御機構の構造基盤の解明
• 新規抗がん剤標的DGKα全長の立体構造基盤の解明

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