Sojo University · Faculty of Pharmaceutical Sciences · 准教授

Research keywordsナノメディシン・ドラッグデリバリーシステム・EPR効果・活性酸素と炎症・がん治療と予防・一酸化炭素・が治療・活性酸素・腫瘍標的化

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• Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide
• The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.
• Singlet Oxygen In Vivo: It Is All about Intensity.
• PH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect

• ハイブリッド抗がんナノメディシンの設計と作用評価
• 腫瘍集積の自己増強を可能とする多機能性ハイブリッドPDTナノ製剤の創製
• 抗ラジカル型抗炎症剤XO阻害剤AHPPの新しいSMA-ミセル化剤の研究
• EPR効果に基づく活性酸素生成型高分子薬の固形癌ターゲティング療法

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