Sojo University · Faculty of Pharmaceutical Sciences · 助教

Research keywords機能性核酸・低分子・核酸化学・有機合成化学

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• Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay
• 2′-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants
• Sequence-Selective 2'-O-Acetyl Modification of RNA Mediated by Duplex Formation with a Reactive Oligonucleotide Probe Incorporating 4-Thio-dT,
• Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries

• リピートRNAに結合し高次構造変化を誘起する新規低分子リガンドの開発
• シトシンN4位の部位特異的アシル基修飾法の開発
• CGGリピートに協奏的に集積する分子を基盤とする脆弱X症候群に対する低分子創薬
• 水素結合形成を基本様式としたpre-miRNA認識分子の開発

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