Sojo University · Faculty of Pharmaceutical Sciences · 准教授

Research keywordsmatrix metalloproteinase activity・ESR diagnostic probes・spin-labeled peptides・nitroxyl radicals・antioxidant scavenging・magnetic resonance imaging・macromolecular contrast agents・vascular abnormalities

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• Development of an ESR-Based Diagnostic Probe for Matrix Metalloproteinase Activity Using a Spin-Labeled Peptide-Conjugated Styrene–Maleic Acid Copolymer2025
• Utilization of the nitroxyl radical TEMPOL to assess scavenging activities of lipid-soluble antioxidants against radicals initiated by the thermal decomposition of 2,2’-azobis(2,4-dimethylvaleronitrile) (AMVN) in ethanol2025
• Comparison of the accumulation manner of a macromolecular drug between two mouse tumour models: study with magnetic resonance imaging and the model macromolecular drug, gadolinium-conjugated dextran.2024
• Protective effects of 2-aminoethylthiosulfuric acid and structurally analogous organosulfur compounds against ionizing radiation.2023

• ビタミンKによる活性酸素生成を作用機序とするMRI可視化抗腫瘍リポソームの作製2022
• がん間質領域に選択的な悪性度指標の磁気共鳴診断法の開発2019
• MRI造影機能を有し酸化ストレス誘導を作用機序とした新規ナノ粒子化抗がん剤の開発2019
• 肝障害の診断と治療を目的としたレドックス感受性リポソームの開発2015

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