Sojo University · Faculty of Biology and Life Sciences · 准教授

Research keywords環境化学物質・核内受容体・乳がん・ビスフェノール・転写制御・ERRγ

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• A novel method to identify and quantify the coactivator proteins that couple with human nuclear receptor: The use of interacting interface α-helix peptide for quantitative inhibition.
• Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor gamma
• Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ)
• Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERR gamma) with high constitutive activity

• 乳がん細胞におけるビスフェノールＡのエストロゲン様活性増強の分子メカニズム
• 低分子量内分泌かく乱化学物質のオーファン核内受容体結合性の迅速解析
• 新世代ビスフェノールの核内受容体を介したシグナル毒性
• ビスフェノールの核内受容体を介した内分泌撹乱シグナル毒性

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