Kumamoto University · Faculty of Medicine, Department of Medicine / Graduate School of Life Sciences (Medical Sciences) / Graduate School of Medical Education · 助教

Research keywords自然免疫・核小体・腫瘍医学・エピジェネティクス・分子生物学・ヒストン修飾

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• RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.
• Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome.
• HPV vaccines induce trained immunity and modulate pro-inflammatory cytokine expression in response to secondary Toll-like receptor stimulations.
• Adjuvant immunotherapy for cancer: both dendritic cell-priming and check-point inhibitor blockade are required for immunotherapy.

• 乳癌の形成・進展における新規ヒストン修飾制御因子の役割
• 核小体恒常性の異常が引き起こす「炎症プライミング」の意義
• 天然変性タンパク質による「ヒストン模倣」現象の作動原理の解明
• B細胞の分化・機能の制御における「内在性ヒストン模倣因子」の役割

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