Kumamoto University · Faculty of Pharmaceutical Sciences / Graduate School of Biomedical Sciences (Pharmaceutical Sciences Division) / Graduate School of Pharmaceutical Education · 教授

Research keywords脳卒中・神経変性・神経炎症・神経薬理学・Neuroscience・Pharmacology・Internal・medicine

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• Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor
• Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity
• Lowering effect of dimethyl-α-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of β-galactosidase-knockout mice
• Retinoid signaling regulates axonal morphology of midbrain dopaminergic neurons

• 切片培養系を用いた中脳ドパミンニューロンの標的組織による保護機序の解析
• 線条体由来蛋白性物質によるドーパミンニューロン死の制御
• 中脳ドパミンニューロンの障害における活性窒素種の複合的作用の解明
• アクアポリン水チャネルの新規機能とそれを応用した抗炎症薬の開発

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