Kurume University · Faculty of Medicine · 准教授

Research keywords生体機能関連化学・酵素化学・ヘムタンパク質・ヘム生合成

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• Heme Regulatory Motif of Heme Oxygenase-2 Is Involved in the Interaction with NADPH–Cytochrome P450 Reductase and Regulates Enzymatic Activity2025 · International Journal of Molecular Sciences, 2025年03月05日,
• Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps2021 · Biochemical Journal, 2021年03月,
• Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction2020 · Antioxidants, 2020年08月,
• Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+ binding2019 · FEBS Letters, 2019年04月,

• 構成型ヘム分解酵素HO-2の酸化還元複合体解析
• 遺伝子組換えP450導入酵母によるハロゲン化合物分子変換システムの開発と性能評価
• 人工変異により高度に活性化されたP450導入酵母による毒物特異的分子変換システム
• ポルフィリン症に関わる酵素の構造生物学的研究

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