Kurume University · Faculty of Medicine · 教授

Research keywordsIBDと疾患感受性遺伝子・疾患感受性遺伝子同定の方法論・連鎖解析からGWASへ

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• Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+ binding.
• Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report.
• Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
• DNA Methylation in Noncancerous Liver Tissues as Biomarker for Multicentric Occurrence of Hepatitis C Virus?Related Hepatocellular Carcinoma.

• エクスポソームによる生活習慣病の発症機序の解明と個別化予防への応用
• 国際コンソーシアムを活用した日本発の痛風の分子疫学研究による予防医学への応用
• 難治性炎症性腸疾患のゲノムおよびエピゲノム解析による病因・病態・治療抵抗性機序の解明 (分担)
• ゲノム科学の総合的推進に向けた大規模ゲノム情報生産・高度情報解析支援

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