Kwansei Gakuin University · Faculty of Life and Environmental Sciences · 教授

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• Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling
• Masanori Kawaguchi, Kota Sugiyama, Kazumi Matsubara, Che-Yi Lin, Shigehiro Kuraku, Shota Hashimoto, Yoshiaki Suwa, Luok Wen Yong, Koji Takino, Shota Higashida, Daisuke Kawamura, Jr-Kai Yu, Yoshiyuki Seki論文
• Critical function of Prdm14 for the establishment of the germ cell lineage in mice.
• Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice

• 始原生殖細胞による細胞増殖を介したエピゲノム情報の希釈と減数分裂能の獲得
• DUXに依存しない胚性ゲノム活性化による全能性獲得機構の解明
• 始原生殖細胞におけるエピゲノムリプログラミングが保証する生命機能の同定
• 生殖細胞形成機構の動物種を超えた共通原理と種特異性

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