Kyoto Pharmaceutical University · Division of Molecular Oncology · 助教

Research fieldsTumor biology

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• Discovery of a Novel γ-Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence-Based High-Throughput Screening.2026 · Cancer science
• Dual inhibition of xCT and GGCT induces ferroptosis in glioblastoma cells by depleting cysteine and disrupting redox homeostasis.2026 · Cell death discovery
• γ-Glutamylcyclotransferase Depletion Induces p15INK4b and p21Cip1-mediated Senescence via TGF-β2/SMAD3 Pathway Activation in Breast Cancer Cells.2026 · Cancer genomics & proteomics
• Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells.2024 · Cancer genomics & proteomics

• GGCT阻害剤と新規ミトコンドリア阻害薬を併用するがん幹細胞阻害戦略の確立2025 · 科学研究費助成事業
• GGCT阻害によるNotch制御機構の解明と膠芽腫幹細胞を標的する新規治療法の確立2023 · 科学研究費助成事業
• GGCTとxCTのダブル阻害によりフェロトーシスを増強する全く新しいがん治療戦略2022 · 科学研究費助成事業
• GGCTによる代謝変容が誘導する新規Hedgehog経路活性化機構の解明2020 · 科学研究費助成事業

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