Kyoto University · Institute for Life and Medical Sciences

Research keywordsapoptosis regulation・ubiquitin ligases・Chk1 cleavage・DDB1 function・protein degradation pathways・disulfide bond activation

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• Activation of disulfide bond cleavage triggered by hydrophobization and lipophilization of functionalized dihydroasparagusic acidOrganic and Biomolecular Chemistry,
• Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.The EMBO Journal,
• Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatinONCOGENE,
• Cleavage-mediated activation of Chk1 during apoptosisJOURNAL OF BIOLOGICAL CHEMISTRY,

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