Kyoto University · Institute for Life and Medical Sciences · 准教授

Research keywordsT-cell fate・innate lymphoid cells・regulatory T cells・Notch signaling・E2A transcription factor・CBP p300・thymic ontogeny・early T progenitors・chronic myelogenous leukemia

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• E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.1950 · Journal of immunology (Baltimore, Md. : 1950),
• Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway.1950 · Journal of immunology (Baltimore, Md. : 1950),
• The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells.1950 · Journal of immunology (Baltimore, Md. : 1950),
• Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer.Biochemical and biophysical research communications,

• ポリコーム遺伝子bmi-1による幼若リンパ球の増殖と細胞死のバランス調節機構
• Regulome調節による獲得免疫リンパ球の確立とRag1/Rag2発現制御
• T細胞の活性化におけるE-Id転写因子による転写調節と細胞内メタボリズムの制御
• 母体の免疫寛容の分子機構の解明と自己寛容増強の新規分子の探索

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