Kyoto University · Institute for Life and Medical Sciences

Research keywordshuman pluripotent stem cells・primordial germ cells・gene targeting・helper-dependent adenoviral vectors・stem cell banking・germline stem cells・hepatic differentiation・stem cell culture substrates

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• Highly efficient transient \ngene expression and gene targeting in human embryonic and induced pluripotent stem cells with helperdependent adenoviral vectors2009 · International Society for Stem Cell Research, 7th Annual Meeting （2009.7.8－11 Barcerona, Spain）,
• Perspectives on the cost of goods for hPSC banks for manufacture of cell therapiesnpj Regenerative Medicine,
• Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product DerivativeJournal of the American Chemical Society,
• Recombinant E8 fragments of human laminin isoforms support long-term culture of human pluripotent stem cells under defined and xeno-free culture conditions.Nature Communications 13, 1236.,

• 幹細胞の維持に不可欠なシグナルが幹細胞ニッチェで局所的に活性化される仕組みの解明
• 化学遺伝学研究法を用いたヒトES細胞の未分化維持・分化制御機構の解明
• 幹細胞ニッチェの形成と維持機構における細胞外環境の役割に関する研究
• ヒトES細胞・ヒトｉＰＳ細胞の均質・大量培養に適した培養法の開発

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