Kyoto University · Institute of Advanced Energy · 助教

Research keywords木質バイオマス・DNA複製・i-motif・in-cell NMR・NMR

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• The first successful observation of in-cell NMR signals of DNA and RNA in living human cellsPhysical Chemistry Chemical Physics (Selected as a HOT article),
• NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAsBiochemical and Biophysical Research Communications,
• Shedding light on the base-pair opening dynamics of nucleic acids in living human cellsNature Communications,
• Multiplicity in Long Noncoding RNA in Living CellsBiomedical Sciences,

• 分子混雑環境下の核酸の運動性解析
• In-cell NMR法を用いたヒト生細胞内核酸の構造安定性および相互作用の評価
• 細胞内における複製開始関連蛋白質とDNAとの複合体構造および相互作用の解析
• カリウムイオン依存的機能スイッチング能をもつ機能性核酸の創製と普遍的設計法の確立

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