Kyoto University · Faculty of Medicine / Graduate School of Medicine · 准教授

Research keywordsRNA分解・造血幹細胞機能制御・癌免疫・慢性炎症・T細胞活性化制御

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• Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.1950 · Journal of immunology (Baltimore, Md. : 1950),
• Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.1950 · Journal of immunology (Baltimore, Md. : 1950),
• Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs.Nucleic acids research,
• A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.Genes & development,

• マテリアル・シンバイオシスのための生命物理化学
• mRNA代謝が司る免疫制御機構の解明
• 非天然核酸が誘導する免疫惹起機構と「弱い相互作用」の解明
• mRNA分解酵素Regnase-1の新規ユビキチン化を介した免疫制御機構の解明

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