Kyoto University · Faculty of Medicine / Graduate School of Medicine

Research keywordsユビキチン・NF-kB・フェロトーシス・鉄代謝・自己免疫疾患

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• Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.52023
• Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon InductionMOLECULAR CELL,
• Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient miceCANCER CELL,
• Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline PolymorphismsCANCER DISCOVERY,

• ユビキチンネオバイオロジー：拡大するタンパク質制御システム
• 低分子G蛋白シグナル系を介した造血系細胞分化制御機構
• 直鎖状ポリユビキチン鎖による選択的NF-κB活性化機構
• ユビキチン系が関与する新規NF-κB活性化機構と炎症との関連

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