Kyoto University · Faculty of Engineering / Graduate School of Engineering · 助教

Research keywordsmitochondrial DNA mutations・reactive oxygen species・lymphoma development・mitochondrial respiration defects・glycolytic metabolism・metastatic progression・transmitochondrial mice

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• Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethalScientific Reports,
• Enhanced glycolysis induced by mtDNA mutations does not regulate metastasisFEBS Letters,
• Erratum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects (Scientific Reports (2015) 5 (10434)) DOI: 10.1038/srep10434)Scientific Reports,
• Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans.Developmental biology,

• マグネシウム再吸収を介した新たな血圧調節機構の解明
• ミトコンドリアからリソソームへの特異的な活性酸素シグナル伝達機構
• 過剰なMgイオンによるミトコンドリアのエネルギー代謝異常とがん悪性化
• マグネシウム再吸収による血圧調節のメカニズム

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