Kyoto University · Center for iPS Cell Research and Application · 教授

Research keywordsGene Therapy・c-Myc・Clinical Hematology・Cell Therapy・骨髄増殖性腫瘍

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• Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy.Molecular therapy. Methods & clinical development,
• Reprogramming away from the exhausted T cell stateSEMINARS IN IMMUNOLOGY,
• Requirements for retroviral targeting of a suicide gene to alloreactive memory stem T cells for adoptive immunotherapy of leukemiaBLOOD,
• Development of a safe and effective stem cell transplantation strategy by the use of antibody-based minimum intensity preconditioning and delayed infusion of suicide-gene transduced donor T lymphocytes in the mouse model of X-linked chronic granulomatous disease (X-CGD)HUMAN GENE THERAPY,

• 多能性幹細胞を用いた免疫遺伝子治療の開発
• 純化造血幹細胞への遺伝子導入による造血器悪性腫瘍モデル開発
• ヒトiPS細胞由来造血幹細胞による小児腫瘍・血液免疫疾患の移植・遺伝子治療の開発
• 多能性幹細胞治療の安全性向上に関する研究

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