Kyoto University · Faculty of Medicine / Graduate School of Medicine · 特定助教

Research keywordsADAR1・RNA editing・cellular senescence・R-loops・telomere genome stability

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• MVH in piRNA processing and gene silencing of retrotransposons.Genes & development,
• Identification of ADAR1i-124: The first effective A-to-I RNA editing inhibitor with promising cancer therapeutic potentialiScience,
• ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levelsNature Cell Biology,
• Comprehensive DNA Methylation Analysis of Retrotransposons in Male Germ Cells.Cell reports,

• 精子幹細胞を用いたpiRNA経路の制御化合物の探索と精巣でのpiRNA経路の制御
• 雄性生殖細胞におけるR-loopの解消機構と精子形成及び次世代への影響
• piRNAを介した生殖細胞の脱分化・腫瘍化制御機構の解明

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