Kyoto University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 講師

Research keywordsmolecular imaging・gastric cancer・radiolabeled antibodies・fluorogenic probes・antibody antigen interaction・tyrosine phosphorylation

Research fieldsバイオ機能応用、バイオプロセス工学・生体化学・Biophysics・薬系化学、創薬科学

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• Selective Detection of Phosphotyrosine in the Presence of Various Phosphate-Containing Biomolecules with the Aid of a Terbium(III) ComplexCHEMBIOCHEM,
• Influence of the Binding Valency of Anti-HER2 Biparatopic Antibodies on Biodistribution in an SK-OV-3 Tumor Xenograft ModelMolecular Pharmaceutics,
• Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicingScientific Reports,
• Unveiling the structural mechanisms behind high affinity and selectivity in phosphorylated epitope-specific rabbit antibodiesJournal of Biological Chemistry,

• 自然免疫型T細胞の機能を利用した新たな創薬モダリティの創出
• バイパラトピック抗体のパネル化による機能的人工抗体の探索デザインの高度化
• 機能的リンカーの導入に基づくバイパラトピック抗体の再設計
• タンパク質リン酸化を選択的に認識する化学プローブの創製

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