Kyoto University · Center for iPS Cell Research and Application

Research keywords臓器再生・膵癌・膵島・多能性幹細胞からの臓器作製・ダイレクトリプログラミング

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• Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells.2018 · Nature cell biology
• Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
• In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells.
• Regulated and adaptive in vivo insulin secretion from islets only containing β-cells.

• 癌腫内に存在する発癌変異を欠く腫瘍上皮細胞の病的意義の解明
• 膵外分泌組織の再生・老化・がんにおけるSenescence/SASPの意義解明
• 胚葉間シグナルによる内胚葉由来臓器の発芽と組織自律的臓器形成の検討
• 臓器境界部形成と境界部前癌病変形成に関わる胚葉間シグナルの解明

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