Kyoto University · Institute for Life and Medical Sciences · 教授

Research keywordsCRISPR-Cas9 screening・acute myeloid leukemia・embryonic stem cells・genome editing・drug target identification・piggyBac transposase・DNA damage response・therapeutic vulnerabilities

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• Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.2000 · Genesis (New York, N.Y. : 2000),
• Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.Nature communications,
• Peroxisomal membrane protein PMP34 is involved in the human papillomavirus infection pathwayFrontiers in Virology,
• Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.Cell,

• CRISPRスクリーニングを用いたヒトiPS細胞の内胚葉系分化機構の解明
• SWI/SNF合成致死遺伝子による造血器腫瘍新規治療戦略の確立
• 腫瘍性fibrocyteの本態解明と、骨髄線維症診断・治療への展開

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