Kyoto University · Faculty of Engineering / Graduate School of Engineering · 准教授

Research keywordschemical proteomics・endogenous protein labeling・bioorthogonal chemistry・covalent protein modification・organelle-selective proteomics・ligand-directed tosyl chemistry・affinity-guided oxime chemistry・photoactivatable proximity labeling・covalent inhibitors・cell-surface receptor labeling

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• In Situ Construction of Protein-Based Semisynthetic BiosensorsACS Sensors,
• Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imagingCurrent Opinion in Chemical Biology,
• Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cellsCHEMICAL COMMUNICATIONS,
• Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structureNature Communications,

• LDT化学による新しい細胞内蛋白質間相互作用解析技術の開発
• オルガネラ代謝物の化学標識による時空間メタボローム解析
• 生命金属動態の理解に向けた金属イオンConditionalプロテオミクス法の開発
• 電位依存性カルシウムチャネルの電子顕微鏡観察を可能にする新規化学修飾法の開発

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