Matsumoto Dental University · Comprehensive Dental Medical Research Institute · 准教授

Research keywordsビタミンD・Bone remodeling・Osteoblast・Osteoclast・Vitamin D・Wnt・破骨細胞・骨代謝

Research fieldsLaboratory animal science・常態系口腔科学・Functional biochemistry

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• Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice.
• Vitamin D in the regulation of osteoclasts
• Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts
• Brain masculinization requires androgen receptor function.（共著）

• 非典型的なＷｎｔ受容体Ｒｙｋシグナルによる骨代謝制御機構の解明
• 細胞種特異的老化モデル創出による老化細胞除去機構の解明と抗フレイル戦略の開拓
• Wntシグナル活性を指標としたプロテオゲノミクス探索解析による骨形成促進薬の開発
• ビタミンDとWntシグナルによる骨ミネラル代謝制御機構に関する基礎的研究

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