Matsuyama University · Faculty of Pharmaceutical Sciences · 准教授

Research keywordsカルボキシルエステラーゼ・薬物代謝・ミトコンドリア

Research fields医療薬学・薬系化学、創薬科学

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• Irreversible extrusion of the first loop facing the matrix of the bovine heart mitochondrial ADP/ATP carrier by labeling the Cys56residue with the SH-reagent methyl methanethiosulfonate
• Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine.
• Membrane potential-dependent conformational changes in mitochondrially bound hexokinase of brain
• TRANSLOCATION OF LOOPS REGULATES TRANSPORT ACTIVITY OF MITOCHONDRIAL ADP-ATP CARRIER DEDUCED FROM FORMATION OF A SPECIFIC INTERMOLECULAR DISULFIDE BRIDGE CATALYZED BY COPPER-O-PHENANTHROLINE

• 2006/04～ プロドラッグ開発を志向した代謝酵素の機能構造解析 個人研究2006 · 研究課題
• エステル含有薬物の分子設計のためのカルボキシルエステラーゼ基質結合領域の構造解析
• 脳特異的なエネルギー代謝を担うヘキソキナーゼの機能制御機構解析と痴呆治療への応用

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