Meiji Pharmaceutical University · Unclassified · 准教授

Research fieldsGenome biology・Molecular biology・Cell biology

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• Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 302025 · Journal of Biological Chemistry. 2025. 301:110522.
• SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.2025 · Mol Cell. 2025. 85(5):894-912.e10. doi: 10.1016/j.molcel.2025.01.008. Epub 2025 Feb 4.
• LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.2019 · Nucleic Acids Res. 2019. 47(19):10357-10372. doi: 10.1093/nar/gkz747.
• TDP-43 regulates site-specific 2'-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs2019 · Nucleic Acids Res. 2019. 47(5):2487-2505. doi: 10.1093/nar/gkz086.

• βサラセミア治療薬を目指すCHTOPを標的としたスプライシング阻害剤の探索
• βサラセミアに対するγグロビンの再発現を介した新規治療法の開発
• RNA エキソソームおよび制御シャペロン複合体の分子モデル構築
• 細胞増殖因子ＬＹＡＲをターゲットとした分子標的薬の探索

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