Meikai University · Department of Oral Biological and Regenerative Medical Engineering · 教授

Research keywordsオートファジー・自然免疫・歯周病

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• Separation of novel phosphoproteins of Porphyromonas gingivalis using phosphate-affinity chromatography.
• Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6.
• Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells.
• Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging.

• デンタルプラーク中の未知の病原因子の特定と歯周炎・誤嚥性肺炎に及ぼす影響の解明
• 加齢に伴うオートファジーの減弱が肺炎・誤嚥性肺炎に及ぼす影響とその制御機構の解明
• Candida albicansの「形態変化」が歯周炎の病態に及ぼす影響の解析
• 歯周病関連細菌が産生する蛋白質の翻訳後修飾：糖鎖修飾とリン酸化修飾の役割

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