Meikai University · Graduate School of Dentistry · 教授

Research keywords免疫・Chemokine・Cytokine・Gene Expression・Immunology・Infection・Inflammation・分子生物学・サイトカイン・Molecular Biology

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• The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene
• Silencing of the interferon-inducible gene Ifi204/p204 induces resistance to interferon-γ-mediated cell growth arrest of tumor cells
• Functional roles of macrophages in periodontal disease: II. Macrophages produce a factor stimulating growth and differentiation of an osteoblastic cell line (MC3T3-E1).
• Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines

• マウスモデルを用いた口腔癌のインターフェロン耐性の生物学的意義の解明
• 口腔癌細胞の遺伝子発現における腫瘍組織微小環境の影響
• TLRシグナル抑制因子を用いた蛋白質療法の開発に関する基礎的研究
• 歯肉線維芽細胞の機能と遺伝子発現に関するサイトカインの調節作用

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