Mie University · Graduate School of Medical Sciences · 教授

Research keywords免疫応答・遺伝子改変Ｔ細胞療法・腫瘍免疫・変異抗原

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• Chimeric antigen receptor T-cell therapy targeting a MAGE A4 peptide and HLA-A*02:01 complex for unresectable advanced or recurrent solid cancer: protocol for a multi-institutional phase 1 clinical trial
• Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.
• Safety and antibody immune response of CHP-NY-ESO-1 vaccine combined with poly-ICLC in advanced or recurrent esophageal cancer patients.
• NY-ESO-1抗原発現と免疫反応は、MAGE-A4ワクチンを受けた食道・頭頸部扁平上皮癌の予後不良と相関する

• 難治性肉腫に対する ワクチン併用TCR遺伝子改変T細胞輸注療法の多施設共同医師主導治験
• 末梢におけるＦＯＸＰ３陽性制御性Ｔ細胞への分化メカニズム解析とがん治療への応用
• 新規免疫応答測定法を利用した複合療法開発への基盤研究
• 難治性食道癌に有効なCAR-T療法のための最適なT細胞選択

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