Mie University · Graduate School of Medical Sciences · 教授

Research keywordsNASH肝発癌・肝細胞癌・胆管癌発癌・肝前駆細胞・IL-6シグナル・IL-33シグナル・脂質代謝異常・アシルカルニチン・MASLD・胆道狭窄内視鏡治療

Research fieldsGastroenterology

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• Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatoheopatitis. 2022.06 J Clin Invest.2022 · 主な業績等
• Axin2+ peribiliary glands in the periampullary region generate biliary epithelial stem cells that give rise to ampullary carcinoma. 2021.05 Gastroenterology.2021 · 主な業績等
• CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. 2018.08 Gut.2018 · 主な業績等
• Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. 2017.05 Proc Natl Acad Sci U S A.2017 · 主な業績等

• 硬化性胆管炎に対する腸内フローラを介した治療法の探索
• 脂質メディエーター作用制御による新たな肝障害治療の試み
• 癌遺伝子変異肝細胞を標的とした発癌抑制システムの解析と新規治療戦略構築
• 血中循環腫瘍デオキシリボ核酸を用いた進行肝癌の個別化治療

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