University of Miyazaki · Department of Medicine / Faculty of Medicine · 助教

Research keywordsparasitic infection pathology・paragonimiasis・Eimeria pragensis・mucosal barrier dysfunction・goblet cell depletion・colon mucin production・hypereosinophilia・intestinal inflammation

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• 一般社団法人 日本内科学会論文
• Introduction: Eimeria pragensis, an intestinal protozoa infecting mice, induces colitis and reduces goblet cell numbers in the large intestine. In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cell down-regulation in the early phase of infection.論文
• Discussion: Our findings suggested that E. pragensis infection induces a mucosal barrier dysfunction in the early phase of the infection, which possibly causes the tissue invasion of bacteria in the large intestine. Th1-type inflammatory response, thus induced, reduces goblet cell numbers and mucin production. This model provides valuable insight into the mechanisms of mucosal barrier disruption during protozoan infection.論文

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