Nagasaki University · Institute of Tropical Medicine

Research keywordsthyrotropin-releasing hormone mimetics・Rovatirelin hydrate・opioid-induced constipation・naldemedine pharmacology・mu-opioid receptor antagonists・anti-hypothermic agents・TRH analog medicinal chemistry・central nervous system therapeutics

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• Synthesis and evaluation of in Vivo anti-hypothermic effect of the N- And C-terminus modified thyrotropin-releasing hormone mimetic: [(4S,5S)-(5-methyl-2-oxooxazolidine-4-yl)-carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide Naotake Kobayashi,Norihito Sato,Katsuji Sugita,Tsuyoshi Kihara,Katsumi Koike,Tamio Sugawara,Yukio Tada,Takayoshi Yoshikawa Chemical and Pharmaceutical Bulletin 69巻4号314頁-324頁 2021年04月2021
• Pharmacologic effects of naldemedine, a peripherally acting μ-opioid receptor antagonist, in in vitro and in vivo models of opioid-induced constipation. Kanemasa T,Koike K,Arai T,Ono H,Horita N,Chiba H,Nakamura A,Morioka Y,Kihara T,Hasegawa M Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 31巻5号e13563頁- 2019年05月2019
• Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{ N-[(4 S,5 S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)- l -alanyl}-(2 R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate) Naotake Kobayashi,Norihito Sato,Yuko Fujimura,Tsuyoshi Kihara,Katsuji Sugita,Kouji Takahashi,Katsumi Koike,Tamio Sugawara,Yukio Tada,Hiroshi Nakai,Takayoshi Yoshikawa ACS Omega 3巻10号13647頁-13666頁 2018年10月19日2018
• Distinct relations among plasma concentrations required for different pharmacological effects in oxycodone, morphine, and fentanyl Atsushi Nakamura,Minoru Hasegawa,Hisanori Ito,Kazuhisa Minami,Katsumi Koike,Naoko Habu-Tomita,Kenkichi Nanba,Kayo Hamaguchi,Eriko Noshi,Hiroshi Hashimoto,Ikuko Nishino,Yoshito Okabayashi,Kiyotaka Koyabu,Tsuyoshi Kihara,Yuka Iwamoto,Yuji Inoue,Minoru Narita,Tsutomu Suzuki,Akira Kato Journal of Pain and Palliative Care Pharmacotherapy 25巻4号318頁-334頁 2011年11月11日2011

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