Nagasaki University · Graduate School of Medicine, Dentistry and Pharmaceutical Sciences · 助教

Research keywordsOsteosarcoma・RUNX3 Signaling・MYC Regulation・P53-Deficient Cancers・Bone Tumor Biology・Tumor-Stroma Interactions・Cancer Genomics

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• Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development of p53-deficient osteosarcoma.
• C/ebpα represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development.
• The periosteum provides a stromal defence against cancer invasion into the bone.
• Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma.

• 骨肉腫発症・進展におけるTGFβ誘導性Myc過剰発現の時空間的制御機構とその役割
• 骨肉腫におけるTGFβ応答性Mycスーパーエンハンサーの意義
• 腫瘍悪性化の起点となるTGFβ作動型転写マシナリーの解明
• 小児骨肉腫発症機序をトレースできる解析モデルの開発

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