Nagasaki University · Faculty of Pharmaceutical Sciences / Graduate School of Medicine, Dentistry and Pharmaceutical Sciences (Pharmaceutical Sciences Division) · 助教

Research keywords神経科学・ノックインマウス・ジスキネジア・シナプス・アルツハイマー病

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• Activity-dependent cleavage of dyskinesia-related proline-rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons.
• Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.
• Proline-rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L-dopa-treated mice.
• Cell type- and neuronal differentiation-dependentMME5′UTR splice variants with distinct translational outputs in human cells

• 動物モデルを用いた発作性運動誘発性ジスキネジアの発症機序の解明と新規治療法の開発
• 小児神経疾患の関連分子PRRT2によるEGFRシグナリングを介した神経発達の調節機序の解析
• 発作性運動誘発性ジスキネジアの時空間的病理形成機序の解明
• 凝集核形成型Aβを優先的に蓄積する革新的アルツハイマー病モデルマウスの開発

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