Nagoya City University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 助教

Research keywordsCa2 signaling・vascular smooth muscle・pulmonary arterial hypertension・blood vessel remodeling・P2X7 receptor・TMEM16A・hepatic stellate cells・STAT3 signaling

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• Mitofusin 2 positively regulates Ca2+ signaling by tethering the sarcoplasmic reticulum and mitochondria in rat aortic smooth muscle cells.
• Increased TMEM16A-mediated Ca2+-activated Cl- currents in portal vein smooth muscle cells of caveolin 1-deficient mice.
• Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review.
• Kir2.1 channels drive macrophage migration through enhancing store-operated Ca2+ entry.

• 肝線維症における肝星細胞のカルシウムシグナル制御機構の解明
• 新規肺高血圧症治療薬を指向したイオンチャネル創薬
• 肝線維症における肝星細胞のイオンチャネル解析と創薬
• 新規肺高血圧症治療薬を指向したイオンチャネル創薬

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