Kio University · Faculty of Health Sciences / Graduate School of Health Sciences · 教授

Research keywordsoncogenic signaling・Ras transformation・EGFR signaling・c-Abl kinase・actin cytoskeleton・phospholipase D・cancer stem-like cells・epithelial tumorigenesis

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• Human diploid broblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras (vol 24, pg 8216, 2005)
• The loss of c-abl facilitates anchorage independent growth of primary mouse embryonic fibroblasts in combination with inactivation of p53 and Rb tumor suppressors
• Antagonistic effects of protein kinase C α and δ on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor
• Cultures derived from pancreatic cancer xenografts with long-term gemcitabine treatment produce chemoresistant secondary xenografts: Establishment of isogenic gemcitabine-sensitive and -resistant models.

• ヒト胎盤由来細胞を利用したNLRP7の機能解析
• 老化幹細胞ニッチにおける筋再生制御に関わる因子の同定
• 瘢痕癒着モデルにおけるハイドロリリースの効果および新しいFasciaモデルの開発

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